No matter what animal you hunt - break the humerus bone and cut the upper chambers of the heart. Lung shots do not work on Africa animals - and in many animals like the kudu and wildebeest there is in any case no lung behind the shoulder.
This Cape buffalo was taken in Zimbabwe a few weeks ago with a .458 Win Mag. The 13th shot was from the PH's .458 Lott putting a 500 gr Peregrine VRG-2 solid through the heart.
Yes, we know the penetration of the .458 Win Mag is poor - but nine bullets were into the lungs.
The thing is - lung shots do not work on Africa game.
Not a happy crew who had a long and unhappy three hours. That game scout's eyes say it all. He is still in shock... :-)