Lion (Panthera leo)
The 100 year old style in Africa has been to take visiting hunters to a bait of zebra or whatever and assassinate a lion while eating, and that is still the way it is done in Zimbabwe.
In South Africa by law any land owner who has dangerous game like lion, elephant, Cape buffalo and hippo on his minimum sized 80,000 acres property has to have a specified fence around it for the safety of neighbours. Lion available for hunting by law has to be free ranging within this property, catching their own meat and not allowed to be fed. Unlike Texas there are no corn feeders... err..sorry... deer dispensers ;-)...
The hunter who gets taken to private land WILL shoot his lion head-on. Face to face, because lion can be pushed for only so long and then they turn on the pusher because they know that somewhere ahead is a fence beyond which escape is impossible. That annoys them.
Your shot will have to be from the one knee kneeling position to have the rifle down at his heart level if he is approaching. He may not charge before about 20 yards but he WILL display a keen interest in one of us. (You will not stand for my bull terrier to approach you in this fashion - take it from me, so do not take hunting lion where a property is fenced as anything else but the real thing). That rifle with which you kill your lion at 20-15 yards you will never sell.
The ideal cartridge for the job is a .458 Win Mag with 510 gr soft point bullets but a .375 H&H or 9.3x62 with heavy, good quality cup and core bullets is good enough.
Is hunter guts needed, and some adrenaline when lion hunting? Only when your PH whispers: "Sshhucks.. Watch that fool female closely but don't shoot her!".